As Sky Sports News confirmed earlier Nemanja Vidic misses the game and is replaced by Wes Brown whilst John O’Shea starts at right back.
On a brighter note, Nani is back in the team and Valencia is again on the bench whilst Hernandez continues up top with Rooney meaning Berbatov has to settle for a spot as a sub.
Starting XI: Van der Sar; O’Shea, Brown, Smalling, Evra; Carrick, Scholes, Nani, Giggs; Rooney, Hernández
Subs: Kuszczak, Berbatov, Fabio, Rafael, Valencia, Obertan, Gibson