United can expect a tough time though as Benfica are undefeated this season and without defensive rock Nemanja Vidic the job will be that much harder.
Ashley Young makes a return to the starting line up following injury whilst Wayne Rooney misses out having failed to train yesterday.
Starting XI:De Gea, Fabio, Jones, Ferdinand, Evra, Valencia, Fletcher, Carrick, Nani, Young, Berbatov
Subs: Lindegaard, Smalling, Rafael, Giggs, Park, Gibson, Hernandez