Fletcher has been out since December but last week it was revealed that he had been training with the Scottish national team, so this is a further step on his road to recovery.
Sir Alex has fielded a team that blends youth and experience in a benefit game for his former player.
Starting XI: David De Gea, Michael Keane, Tyler Blackett, Thomas Thorpe, Rio Ferdinand (Captain), Nicholas Powell, Anderson, Federico Macheda, Bebe, Ryan Giggs, Paul Scholes
Subs: Larnell Cole, Clayton Blackmore, Samuel Johnstone, Darren Fletcher, Quinton Fortune, Adnan Januzaj, Dwight Yorke